What are the Causes of Cirrhosis?
Cirrhosis can be caused by a number of conditions, including long-standing
inflammation, poisons, infections, and heart disease, as well as chronic
alcoholism and chronic hepatitis, the most common causes.
Chronic Alcoholism :
Alcohol can poison living cells, causing liver cells to become inflamed and
- The death of liver cells leads your body to form scar tissue around
veins of your liver. Healing liver cells form nodules, which also press
on the liver veins.
- This scarring process occurs in 10-20 percent of alcoholics and is
the most common form of cirrhosis in the United States.
- The severity of the process depends on how much you drink and how
long you have been abusing alcohol. The amount of alcohol needed to
injure the liver varies widely from individual to individual.
- Some families are more susceptible to cirrhosis than others.
Hepatitis means inflammation of the liver from any cause, but it usually
refers to a viral infection of the liver.
Autoimmune Cirrhosis :
- Over many years the inflammation damages liver cells and leads to
- Hepatitis B, hepatitis C, and hepatitis D all can cause cirrhosis.
- Worldwide, hepatitis B is the most common cause of cirrhosis, but in
the United States hepatitis C is a more common cause.
- Biliary cirrhosis: Bile is a substance produced by the liver to help
the body digest fats. If the ducts carrying bile out of liver get
blocked it can cause inflammation of liver cells leading to cirrhosis.
Autoimmune diseases occur when the immune system instead begins to fight
healthy body tissues and organs.In autoimmune hepatitis, the body's immune
system attacks the liver, causing cell damage that leads to cirrhosis.
Nonalcoholic Fatty Liver :
This is a condition in which fat builds up in the liver, eventually causing
scar tissue to form It is associated with diabetes, obesity, coronary artery
disease, protein malnutrition.It is sometimes called "Steatohepatitis."
Inherited Diseases :
A variety of genetic diseases can damage the liver.They include Wilson's
disease, cystic fibrosis, alpha-1 antitrypsin deficiency, hemochromatosis,
galactosemia, and glycogen storage disease.
Drugs, Toxins, and Infections :
Various substances and germs can cause damage to the liver (for example,
acetaminophen), poisons, and environmental toxins can lead to cirrhosis.
Cardiac Cirrhosis :
Your heart is a pump that pushes blood throughout your body. When your
heart doesn't pump well, blood "backs up" into the liver. This
congestion causes damage to your liver.